- Allmymusic 3 0 1 5 Ml
- Allmymusic 3 0 1 5 Ml Ounces
- Allmymusic 3 0 1 5 Ml Equals
- Allmymusic 3 0 1 5 Ml Look Like
- Allmymusic 3 0 1 5 Ml Eppendorf Tube
1:5 1:10 1:20 Example: You have 7.5 mL of sample and want to prepare 1:10 dilution. X – = Weight of Sample Dilution Weight of Sample 7.5 mL 10 7.5 mL 67.5 mL Volume of Bu˜er Needed 11.00 g 1:20 Dilution Sample size Diluent 1:5 1:10 10.00 g 22.50 g 24.75 g 1.00 g 10.00 g 4.74 g 5.21 g mL mL mL mL mL mL or 40 90 99 90 99 90 99 9 mL mL or or. AllMyMusic 2.4.3 Free Download for Mac - High-quality recorder for streaming audio. With Wondershare's AllMyMusic Full version download for Mac, an unlimited supply of totally free music is also just the click away. Want so that you can listen to your chosen songs, radio app AllMyMusic,Music,AllMyMusic for Mac,Music for Mac,AllMyMusic Download, AllMyMusic Free Download, AllMyMusic Full.
Medically reviewed by Drugs.com. Last updated on May 28, 2020.
Applies to the following strengths: 8 mEq; 10 mEq; 20 mEq; 40 mEq/15 mL; 20 mEq/15 mL; 2 mEq/mL; 1.5 mEq/mL; 10 mEq/100 mL; 10 mEq/50 mL; 20 mEq/100 mL; 30 mEq/100 mL; 20 mEq/50 mL; 40 mEq/100 mL; 500 mg; 25 mEq; 15 mEq; 30 mEq/15 mL; 6.7 mEq; 3 mEq/mL; 99 mg; 40 mEq/250 mL-NaCl 0.9%; 40 mEq/500 mL-NaCl 0.9%; 50 mEq/500 mL-LR; 20 mEq/250 mL-NaCl 0.9%; 4 mEq/10 mL-NaCl 0.9%; 2 mEq/5 mL-NaCl 0.9%; 3 mEq/7.5 mL-NaCl 0.9%; 595 mg
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Hypokalemia
Oral:
40 to 100 mEq per day, orally, in 2 to 5 divided doses
Maximum single dose: 20 mEq per dose
Maximum daily dose: 200 mEq
Parenteral (must be diluted prior to administration):
Dose and rate of administration are dependent on patient condition
-If serum potassium is 2.5 mEq/L or higher, rate should not exceed 10 mEq/hour, and manufacturers recommend that concentration not exceed 40 mEq/L
Maximum daily dose: 200 mEq
-If treatment is urgent (serum potassium less than 2 mEq/L and electrocardiographic changes and/or muscle paralysis), infuse cautiously at up to 40 mEq/hour with continuous cardiac monitoring
Maximum daily dose: 400 mEq
-In critical situations, may administer in saline rather than dextrose (dextrose may lower serum potassium)
Comments:
-Never give injectable potassium chloride undiluted.
-The usual adult dietary intake is 50 to 100 mEq potassium per day.
-Potassium depletion sufficient to cause hypokalemia usually requires the loss of 200 mEq or more of the total body stores of potassium.
Usual Adult Dose for Prevention of Hypokalemia
Oral:
Typical dose: 20 mEq, orally, daily
-Individualize dose based on serum potassium levels
-Divide dose if more than 20 mEq per day is used
Parenteral (must be diluted prior to administration):
Dose and rate of administration are dependent on patient condition
-If serum potassium is 2.5 mEq/L or higher, rate should not exceed 10 mEq/hour, and manufacturers recommend that concentration not exceed 40 mEq/L
Maximum daily dose: 200 mEq
Comments:
-Never give injectable potassium chloride undiluted
-The usual adult dietary intake is 50 to 100 mEq potassium per day.
Usual Pediatric Dose for Hypokalemia
Birth to 16 years:
Oral solution:
Initial dose: 2 to 4 mEq/kg/day, orally, in divided doses
-Limit to 1 mEq/kg or 40 mEq per dose, whichever is lower
Maximum daily dose: 100 mEq
Parenteral (must be diluted prior to administration):
Dose and rate of administration are dependent on patient condition
-If serum potassium is 2.5 mEq/L or higher, rate should not exceed 10 mEq/hour, and manufacturers recommend that concentration not exceed 40 mEq/L
Maximum daily dose: 200 mEq
-If treatment is urgent (serum potassium less than 2 mEq/L and electrocardiographic changes and/or muscle paralysis), infuse cautiously at up to 40 mEq/hour with continuous cardiac monitoring
Maximum daily dose: 400 mEq
-In critical situations, may administer in saline rather than dextrose (dextrose may lower serum potassium)
Comments:
-Never give injectable potassium chloride undiluted
Allmymusic 3 0 1 5 Ml
Usual Pediatric Dose for Prevention of Hypokalemia
Birth to 16 years:
Oral solution:
Initial dose: 1 mEq/kg/day, orally
Maximum daily dose: 3 mEq/kg/day
Intravenous (must be diluted prior to administration):
Dose and rate of administration are dependent on patient condition
-If serum potassium is 2.5 mEq/L or higher, rate should not exceed 10 mEq/hour, and manufacturers recommend that concentration not exceed 40 mEq/L
Maximum daily dose: 200 mEq
Comments:
-Never give injectable potassium chloride undiluted
Renal Dose Adjustments
Contraindicated in renal failure.
-May cause potassium intoxication and life-threatening hyperkalemia in patients with renal insufficiency due to reduced urinary excretion.
-Start mildly renally impaired patients, particularly if a concomitant renin-angiotensin-aldosterone inhibitor is used, on the low end of the dose range and monitor serum potassium frequently.
-Assess renal function periodically.
-Use of the dextrose containing injection may cause hyperkalemia, hyponatremia, and/or fluid overload in renally impaired patients; monitor for these reactions.
Liver Dose Adjustments
Use with caution.
-Published literature shows cirrhotic patients had baseline corrected serum potassium concentrations (measured 3 hours after oral administration) about twice that of normal subjects.
-It is recommended to start cirrhotic patients on the low end of the dose range and monitor serum potassium periodically.
Dose Adjustments
Initial dosages may be adjusted to specific patient needs based on steady state serum potassium concentrations.
Geriatrics:
-Clinical studies did not have sufficient numbers of patients 65 and older to determine if they respond differently than younger subjects, nor has reported clinical experience identified differences.
-In general, use caution, starting on the low end of the dose range, due to the likelihood of decreased hepatic, renal, or cardiac function; monitor serum potassium periodically.
Precautions
Rectangle macos. CONTRAINDICATIONS:
-Hypersensitivity to any of the ingredients
-Clinically significant hyperkalemia
-Clinically significant hyperglycemia (potassium chloride in dextrose injection)
-Concomitant potassium sparing diuretics (oral formulations)
Safety and efficacy of oral formulations have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Potassium chloride is dialyzable; however, no dose adjustment guidelines have been reported.
-Dialysis may be used for treatment of overdosage.
Other Comments
Administration advice:
-Never give injectable potassium chloride undiluted.
-Do not infuse rapidly.
-Administer oral potassium with or after food to minimize gastric irritation.
Patient advice:
-Take oral potassium with meals and a full glass of water or other liquids.
-Take this medication as prescribed.
-Check with your physician at once if tarry stools or other signs of gastrointestinal bleeding are noticed.
More about potassium chloride
- During Pregnancy or Patient Tips
Consumer resources
- Other brands
- Klor-Con, K-Dur
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by Drugs.com. Last updated on Nov 2, 2020.
Applies to the following strengths: valerate 40 mg/mL; valerate 10 mg/mL; valerate 20 mg/mL; cypionate 5 mg/mL; 0.05 mg/24 hr; 0.1 mg/24 hr; 0.025 mg/24 hours twice weekly; 0.05 mg/24 hours twice weekly; 0.075 mg/24 hours twice weekly; 0.1 mg/24 hours twice weekly; 0.52 mg/0.87 g (0.06%); 0.75 mg/1.25 g (0.06%); 0.025 mg/24 hours weekly; 0.0375 mg/24 hours twice weekly; 0.5 mg; 1 mg; 2 mg; 0.25 mg/0.25 g (0.1%); 0.5 mg/0.5 g (0.1%); 1 mg/1 g (0.1%); 0.05 mg/24 hours weekly; 0.075 mg/24 hours weekly; 0.1 mg/24 hours weekly; 0.0375 mg/24 hours weekly; 0.06 mg/24 hours weekly; 1.5 mg; acetate 0.45 mg; acetate 0.9 mg; acetate 1.8 mg; 1.53 mg/spray; benzoate; valerate; 14 mcg/24 hours weekly; hemihydrate; 0.75 mg/0.75 g (0.1%); 1.25 mg/1.25 g (0.1%)
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Postmenopausal Symptoms
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1 to 5 mg intramuscularly every 3 to 4 weeks
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
-Administration should be cyclic (e.g. 3 weeks on, 1 week off)
Topical gel: 1 pump of gel once a day, applied as a thin layer
Topical spray:
Initial dose: 1 spray once a day, to the inner surface of the forearm, starting near the elbow
Maintenance dose: 1 to 3 sprays once a day to adjacent, non-overlapping areas on the inner surface of the forearm
-Application site should not be washed for at least 1 hour
Transdermal film: 1 film, applied twice weekly
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Vaginal insert:
Initial dose: 10 mcg; 1 insert intravaginally daily for 2 weeks, followed by 1 insert twice weekly (e.g. Tuesday and Friday)
Comments:
-When prescribed for a woman with a uterus, consider adding a progestin to reduce endometrial cancer risk.
-Women without uteruses generally do not need a progestin, but those with a history of endometriosis may need a progestin.
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
-Attempt to discontinue or taper at 3 to 6 month intervals.
Usual Adult Dose for Atrophic Urethritis
Allmymusic 3 0 1 5 Ml Ounces
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1 to 5 mg intramuscularly every 3 to 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
-Administration should be cyclic (e.g. 3 weeks on, 1 week off)
Topical gel: 1.25 grams of gel once a day, applied as a thin layer over the entire arm, inside and outside, from wrist to shoulder
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Vaginal cream:
Initial dose: 2 to 4 grams intravaginally once a day for 2 weeks, then reduce dose by half for a similar period.
Maintenance dose: 1 gram, three times a week - use after restoration of vaginal mucosa has been achieved
Vaginal tablets and inserts:
Initial dose: 10 mcg
-1 tablet/insert intravaginally once a day for 2 weeks, followed by 1 tablet/insert twice weekly (e.g. Tuesday and Friday)
Vaginal ring:
Initial dose: 0.05 mg/day ring, intravaginally; change every 90 days
Comments:
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
Usual Adult Dose for Atrophic Vaginitis
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1 to 5 mg intramuscularly every 3 to 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
-Administration should be cyclic (e.g. 3 weeks on, 1 week off)
Topical gel: 1.25 grams of gel once a day, applied as a thin layer over the entire arm, inside and outside, from wrist to shoulder
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Vaginal cream:
Initial dose: 2 to 4 grams intravaginally once a day for 2 weeks, then reduce dose by half for a similar period.
Maintenance dose: 1 gram, three times a week - use after restoration of vaginal mucosa has been achieved
Vaginal tablets and inserts:
Initial dose: 10 mcg
-1 tablet/insert intravaginally once a day for 2 weeks, followed by 1 tablet/insert twice weekly (e.g. Tuesday and Friday)
Vaginal ring:
Initial dose: 0.05 mg/day ring, intravaginally; change every 90 days
Comments:
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
Usual Pediatric Dose for Hypokalemia
Birth to 16 years:
Oral solution:
Initial dose: 2 to 4 mEq/kg/day, orally, in divided doses
-Limit to 1 mEq/kg or 40 mEq per dose, whichever is lower
Maximum daily dose: 100 mEq
Parenteral (must be diluted prior to administration):
Dose and rate of administration are dependent on patient condition
-If serum potassium is 2.5 mEq/L or higher, rate should not exceed 10 mEq/hour, and manufacturers recommend that concentration not exceed 40 mEq/L
Maximum daily dose: 200 mEq
-If treatment is urgent (serum potassium less than 2 mEq/L and electrocardiographic changes and/or muscle paralysis), infuse cautiously at up to 40 mEq/hour with continuous cardiac monitoring
Maximum daily dose: 400 mEq
-In critical situations, may administer in saline rather than dextrose (dextrose may lower serum potassium)
Comments:
-Never give injectable potassium chloride undiluted
Allmymusic 3 0 1 5 Ml
Usual Pediatric Dose for Prevention of Hypokalemia
Birth to 16 years:
Oral solution:
Initial dose: 1 mEq/kg/day, orally
Maximum daily dose: 3 mEq/kg/day
Intravenous (must be diluted prior to administration):
Dose and rate of administration are dependent on patient condition
-If serum potassium is 2.5 mEq/L or higher, rate should not exceed 10 mEq/hour, and manufacturers recommend that concentration not exceed 40 mEq/L
Maximum daily dose: 200 mEq
Comments:
-Never give injectable potassium chloride undiluted
Renal Dose Adjustments
Contraindicated in renal failure.
-May cause potassium intoxication and life-threatening hyperkalemia in patients with renal insufficiency due to reduced urinary excretion.
-Start mildly renally impaired patients, particularly if a concomitant renin-angiotensin-aldosterone inhibitor is used, on the low end of the dose range and monitor serum potassium frequently.
-Assess renal function periodically.
-Use of the dextrose containing injection may cause hyperkalemia, hyponatremia, and/or fluid overload in renally impaired patients; monitor for these reactions.
Liver Dose Adjustments
Use with caution.
-Published literature shows cirrhotic patients had baseline corrected serum potassium concentrations (measured 3 hours after oral administration) about twice that of normal subjects.
-It is recommended to start cirrhotic patients on the low end of the dose range and monitor serum potassium periodically.
Dose Adjustments
Initial dosages may be adjusted to specific patient needs based on steady state serum potassium concentrations.
Geriatrics:
-Clinical studies did not have sufficient numbers of patients 65 and older to determine if they respond differently than younger subjects, nor has reported clinical experience identified differences.
-In general, use caution, starting on the low end of the dose range, due to the likelihood of decreased hepatic, renal, or cardiac function; monitor serum potassium periodically.
Precautions
Rectangle macos. CONTRAINDICATIONS:
-Hypersensitivity to any of the ingredients
-Clinically significant hyperkalemia
-Clinically significant hyperglycemia (potassium chloride in dextrose injection)
-Concomitant potassium sparing diuretics (oral formulations)
Safety and efficacy of oral formulations have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Potassium chloride is dialyzable; however, no dose adjustment guidelines have been reported.
-Dialysis may be used for treatment of overdosage.
Other Comments
Administration advice:
-Never give injectable potassium chloride undiluted.
-Do not infuse rapidly.
-Administer oral potassium with or after food to minimize gastric irritation.
Patient advice:
-Take oral potassium with meals and a full glass of water or other liquids.
-Take this medication as prescribed.
-Check with your physician at once if tarry stools or other signs of gastrointestinal bleeding are noticed.
More about potassium chloride
- During Pregnancy or Patient Tips
Consumer resources
- Other brands
- Klor-Con, K-Dur
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by Drugs.com. Last updated on Nov 2, 2020.
Applies to the following strengths: valerate 40 mg/mL; valerate 10 mg/mL; valerate 20 mg/mL; cypionate 5 mg/mL; 0.05 mg/24 hr; 0.1 mg/24 hr; 0.025 mg/24 hours twice weekly; 0.05 mg/24 hours twice weekly; 0.075 mg/24 hours twice weekly; 0.1 mg/24 hours twice weekly; 0.52 mg/0.87 g (0.06%); 0.75 mg/1.25 g (0.06%); 0.025 mg/24 hours weekly; 0.0375 mg/24 hours twice weekly; 0.5 mg; 1 mg; 2 mg; 0.25 mg/0.25 g (0.1%); 0.5 mg/0.5 g (0.1%); 1 mg/1 g (0.1%); 0.05 mg/24 hours weekly; 0.075 mg/24 hours weekly; 0.1 mg/24 hours weekly; 0.0375 mg/24 hours weekly; 0.06 mg/24 hours weekly; 1.5 mg; acetate 0.45 mg; acetate 0.9 mg; acetate 1.8 mg; 1.53 mg/spray; benzoate; valerate; 14 mcg/24 hours weekly; hemihydrate; 0.75 mg/0.75 g (0.1%); 1.25 mg/1.25 g (0.1%)
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Postmenopausal Symptoms
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1 to 5 mg intramuscularly every 3 to 4 weeks
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
-Administration should be cyclic (e.g. 3 weeks on, 1 week off)
Topical gel: 1 pump of gel once a day, applied as a thin layer
Topical spray:
Initial dose: 1 spray once a day, to the inner surface of the forearm, starting near the elbow
Maintenance dose: 1 to 3 sprays once a day to adjacent, non-overlapping areas on the inner surface of the forearm
-Application site should not be washed for at least 1 hour
Transdermal film: 1 film, applied twice weekly
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Vaginal insert:
Initial dose: 10 mcg; 1 insert intravaginally daily for 2 weeks, followed by 1 insert twice weekly (e.g. Tuesday and Friday)
Comments:
-When prescribed for a woman with a uterus, consider adding a progestin to reduce endometrial cancer risk.
-Women without uteruses generally do not need a progestin, but those with a history of endometriosis may need a progestin.
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
-Attempt to discontinue or taper at 3 to 6 month intervals.
Usual Adult Dose for Atrophic Urethritis
Allmymusic 3 0 1 5 Ml Ounces
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1 to 5 mg intramuscularly every 3 to 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
-Administration should be cyclic (e.g. 3 weeks on, 1 week off)
Topical gel: 1.25 grams of gel once a day, applied as a thin layer over the entire arm, inside and outside, from wrist to shoulder
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Vaginal cream:
Initial dose: 2 to 4 grams intravaginally once a day for 2 weeks, then reduce dose by half for a similar period.
Maintenance dose: 1 gram, three times a week - use after restoration of vaginal mucosa has been achieved
Vaginal tablets and inserts:
Initial dose: 10 mcg
-1 tablet/insert intravaginally once a day for 2 weeks, followed by 1 tablet/insert twice weekly (e.g. Tuesday and Friday)
Vaginal ring:
Initial dose: 0.05 mg/day ring, intravaginally; change every 90 days
Comments:
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
Usual Adult Dose for Atrophic Vaginitis
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1 to 5 mg intramuscularly every 3 to 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
-Attempt to discontinue or taper at 3 to 6 month intervals
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
-Administration should be cyclic (e.g. 3 weeks on, 1 week off)
Topical gel: 1.25 grams of gel once a day, applied as a thin layer over the entire arm, inside and outside, from wrist to shoulder
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Vaginal cream:
Initial dose: 2 to 4 grams intravaginally once a day for 2 weeks, then reduce dose by half for a similar period.
Maintenance dose: 1 gram, three times a week - use after restoration of vaginal mucosa has been achieved
Vaginal tablets and inserts:
Initial dose: 10 mcg
-1 tablet/insert intravaginally once a day for 2 weeks, followed by 1 tablet/insert twice weekly (e.g. Tuesday and Friday)
Vaginal ring:
Initial dose: 0.05 mg/day ring, intravaginally; change every 90 days
Comments:
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
Usual Adult Dose for Hypoestrogenism
Depo-estradiol (estradiol cypionate) for injection:
Usual dose: 1.5 to 2 mg intramuscularly every 4 weeks
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
Comments:
-Adjust dose as needed to control symptoms.
Uses: Treatment of female hypoestrogenism due to hypogonadism, castration, or primary ovarian failure.
Usual Adult Dose for Oophorectomy
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Usual Adult Dose for Primary Ovarian Failure
Oral tablets:
Initial dose: 1 to 2 mg orally once a day
Injectable estradiol valerate:
Usual dose: 10 to 20 mg intramuscularly every 4 weeks
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Usual Adult Dose for Breast Cancer-Palliative
Oral tablets: 10 mg orally 3 times a day for at least 3 months
Usual Adult Dose for Osteoporosis
Transdermal film: 1 film, applied twice weekly
Transdermal patches: 1 patch, applied weekly
-Some patches are applied twice a week: the manufacturer product information should be consulted.
Oral tablets - lowest effective dose has not been determined
Comments:
-If using solely for postmenopausal osteoporosis prevention, use only for significant risk when non-estrogen medications are not appropriate.
Usual Adult Dose for Prostate Cancer
Oral tablets: 1 to 2 mg orally 3 times a day
Injectable estradiol valerate:
Usual dose: 30 mg or more intramuscularly every 1 to 2 weeks
Comments:
-For palliation only.
-Effectiveness of therapy can be judged by phosphatase determinations and symptomatic improvement.
Use: Palliation of advanced androgen-dependent prostate carcinoma
Renal Dose Adjustments
Data not available
-Carefully observe patients with renal impairment.
Liver Dose Adjustments
Contraindicated
Allmymusic 3 0 1 5 Ml Equals
Precautions
US BOXED WARNING(S):
CARDIOVASCULAR DISORDERS, BREAST CANCER, ENDOMETRIAL CANCER, AND PROBABLE DEMENTIA
Estrogen Plus Progestin Therapy:
--Cardiovascular Disorders and Probable Dementia
-Estrogen plus progestin therapy should not be used for prevention of cardiovascular disease or dementia.
-The Women's Health Initiative (WHI) estrogen plus progestin substudy reported an increased risk of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and myocardial infarction (MI) in postmenopausal women (50 to 79 years old) taking conjugated estrogens (CE) (0.625 mg) combined with medroxyprogesterone acetate (MPA) (2.5 mg) for 5.6 years, compared to placebo.
-The WHI Memory Study (WHIMS) estrogen plus progestin ancillary study reported an increase of developing probable dementia in postmenopausal women over 65 years old treated with daily CE (0.625 mg) with MPA (2.5 mg) compared to placebo; it is unknown if this applies to younger postmenopausal women.
--Breast Cancer
-The WHI estrogen plus progestin substudy reported an increased risk of invasive breast cancer.
-Lacking comparable data, assume the risk is similar for other doses of CE and MPA doses, and other combinations and dosage forms of estrogens and progestins.
Estrogen Alone Therapy:
--Endometrial Cancer
-Endometrial cancer risk is increased in a woman with a uterus using unopposed estrogens.
-Adding a progestin to estrogen therapy reduces the risk of endometrial hyperplasia, which may be an endometrial cancer precursor.
-Perform diagnostic measures, including directed or random endometrial sampling when indicated, to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding.
--Cardiovascular Disorders and Probable Dementia
-Estrogen alone therapy should not be used for prevention of cardiovascular disease or dementia.
-The WHI estrogen-alone ancillary study reported increased risks of stroke and DVT in postmenopausal women (50 to 79 years old) taking daily CE (0.625 mg) for 7.1 years, relative to placebo.
-The WHIMS estrogen-alone ancillary study reported an increased risk of probable dementia in postmenopausal women over 65 taking daily CE (0.625 mg) for 5.2 years, relative to placebo; it is unknown if this applies to younger postmenopausal women.
-Lacking comparable data, assume the risk is similar for other doses and dosage forms of estrogens.
Recommendation:
-Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
More about estradiol
Allmymusic 3 0 1 5 Ml Look Like
- During Pregnancy or Breastfeeding
Consumer resources
- Other brands
- Estrace, Climara, Vivelle-Dot, Estradiol Patch, .. +17 more
Professional resources
Related treatment guides
Allmymusic 3 0 1 5 Ml Eppendorf Tube
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
